Neuronal circuits in our brain are known to be plastic and are subject to experience-driven changes causing neurons to modify their structure, and functional connectivity and responses. Synaptic plasticity refers to the ability of the neuron to reorganize its synaptic connections and functions in response to alterations in sensory experience or learning. It is established that various cardiovascular disease (CVD) would impair cognitive function such as learning and memory. However, it remains unclear how CVD leads to cognitive deficits. Our group aims to apply different cutting-edge optical imaging methods combined with molecular approaches to dissect the underlying mechanisms and seek novel treatment strategies.